With an increasing concern on sustainability, there are various attempts to leverage business capability to achieve green management performance. Since supply chain management is core mechanism underlying business competitiveness, movement in green management activities is strong. Green supply chain management involves diverse activities to ensure effective management of negative environmental impacts. Eco-design plays a vital role in fostering green management from upstream to downstream activities. With the concept of Life cycle, manufacturers are able to view the effect of green management activities on supply chain design and practices. This study aims to determine priority of eco-design practices toward green supply chain management. This study employs interpretive structural modeling (ISM) and MIMAC to identify the hierarchical structure of the relationship between variables and analyze the characteristic power of each variable on supporting the eco design practices. It determines indicators that are effective to an enhancement of eco-design practice which affect green supply chain management performance.