Due to increasing emphasis on sustainable practices, many organisations have attempted to leverage their supply chain performance towards balancing triple bottom line dimensions (economic, environmental and social perspectives). This paper, therefore, determines the priorities of sustainable supply chain management focusing on eco-design. Interpretive structural modelling (ISM) and Matriced’ Impacts Croise’s Multiplication Appliquée a UN Classement (MIMAC) are used to identify the hierarchical structure of the relationships among eco-design dimensions, and to analyse characteristics power of each dimension on supporting eco-design practices. The relationships and characteristics power of each dimension are used to determine indicators that are effective in enhancement of eco-design practice, evaluated through sustainable supply chain performance. Results indicate that product deployment is an important approach for improving eco-design practice towards sustainable supply chain management. This emphasises the purpose and impact of eco-design on sequential supply chain activities at deployment phase. Further research is required to make an overall assessment ofeco-design practices across range of manufacturing industries, given the current research is based on inputs from a limited number of experts of selected organisations. © 2017 Informa UK Limited, trading as Taylor & Francis Group