This paper focuses on making daily decision on assigning nurses to patients. Current nurse assignment methods do not emphasize on balancing workload for nurses, which usually lead to nurses’ excess workload and dissatisfaction. We develop a computerized nurse assignment prototype, which tailored to Medical-Surgical units in the Northeast Texas hospital. We describe a mixed integer programming model for assigning nurses to patients with an objective to balance nurses’ workload. New additional constraints with respect to room location policy, patient requirement for specialized nurse, and roles of nurses are proposed to enhance a decision making process. Then, the structure of the computerized nurse-patient assignment prototype is presented. Furthermore, computerized prototype implementation along with its development process is described. Finally, positive results from potential users supporting the use of the prototype in their workplaces are discussed.